According to figures from industry tracker Exhibitor Relations, the highly-anticipated 18th entry in the Marvel Cinematic Universe earned $192 million over Friday, Saturday and Sunday -- exceeding predictions of $170 million.
Thanks to Presidents' Day in the US on Monday, "Black Panther's" estimated earnings were boosted to a stratospheric $218 million -- crushing "Deadpool's" 2016 Presidents' Day record of $152.1 million.
The film, from Disney-owned Marvel Studios, features a star-studded, almost entirely black cast led by Chadwick Boseman as the first non-white superhero to get his own stand-alone movie in the franchise.
Starring alongside Michael B Jordan and Lupita Nyong'o, Boseman plays the titular superhero also known as T'Challa, king and protector of the technologically advanced fictional African nation of Wakanda, an affluent, never-colonized utopia.
In at second was family-friendly "Peter Rabbit," based on Beatrix Potter's classic children's book. Mixing live actors with computer-generated animation, it brought in an estimated $22.1 million over the holiday weekend for total earnings of $53.1 million.
James Corden voices the lead bunny which feuds with garden owner Domhnall Gleeson for the affections of sweet-hearted neighbor Rose Byrne.
Dropping to third was last week's box office champion, Universal's "Fifty Shades Freed," with takings of $19 million, down from $38.6 million the previous week.
Starring Dakota Johnson as English lit major-turned-publisher Anastasia Steele and Jamie Dornan as Christian Grey, her kinky lover-turned-husband, "Freed" is the last of the "Fifty Shades" trilogy, which has enjoyed massive popularity among primarily female audiences.
Sony's "Jumanji: Welcome to the Jungle" placed fourth in its ninth week in theaters, matching last week's earnings with $10 million.
Featuring Dwayne "The Rock" Johnson, Kevin Hart and Jack Black, the family film tells the tale of a group of teens transported inside a video game world.
Director Clint Eastwood's "The 15:17" dropped two places into fifth, taking $9 million.
The film recounts the story of three young Americans who foiled a terrorist attack on board a train in France in 2015. In an alternative approach that divided critics, Eastwood cast the three men -- none of whom had any acting experience -- to play themselves.
Rounding out the top 10 were:
"The Greatest Showman" ($6.3 million)
"Early Man" ($4.2 million)
"Maze Runner: The Death Cure" ($3 million)
"Winchester" ($2.7 million)
"Samson" ($2.4 million)
- Countries: None